Tyrosinase inhibitors from cumin

Kubo, I.; Kinst-Hori, I.

Tyrosinase inhibitors from cumin

1998

Kubo, I. | Kinst-Hori, I.

Cuminaldehyde (p-isopropylbenzaldehyde) was identified as a potent mushroom tyrosinase inhibitor from cumin, a common food spice. This benzaldehyde derivative was found to inhibit the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase with an ID50 of 7.7 micrograms/mL (0.05 mM). Its oxidized analogue, cumic acid (p-isopropylbenzoic acid), was also characterized to inhibit this oxidation with an ID50 of 43 micrograms/mL (0.26 mM). These two inhibitors affect mushroom tyrosinase activity in different ways.

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