Vitamin C and acute illness in Navajo schoolchildren
1976
Coulehan, John L.
Extract: A double blind trial of vitamin C versus placebo among 868 Navajo schoolchildren was conducted to evaluate the usefulness of vitamin C in managing the common cold. There was no difference in number becoming ill, number of episodes or mean illness duration between the groups. Children receiving vitamin C had fewer throat cultures yielding beta hemolytic streptococcus, but no difference in overall complicated illness rate. Plasma ascorbic acid levels were higher in the vitamin group 25 to 26 hours after supplementation. Children with high plasma ascorbic acid concentrations had longer mean illness than those with low levels. Vitamin C does not seem to be an effective prophylactic or therapeutic agent for upper respiratory illness.
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