A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions
2018
La, Minh Thanh | Kim, Hee-Kwon
A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride·diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of tert-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.
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书目信息
Tetrahedron
卷
74
期
27
页码
3748
- 3754
ISSN
0040-4020
出版者
Elsevier Ltd
其它主题
Carboxylic acid; Boron trifluoride·diethyl etherate; Moieties; Protecting groups; Tert-butyl ester; Ambient temperature
语言
英语
类型
Journal Article; Text
2024-02-28
MODS