Deciphering Functions of Branched Ubiquitin Chains
2014
López-Mosqueda, Jaime | Dikic, Ivan
The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.
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书目信息
出版者
Elsevier Inc.
其它主题
Ubiquitin; Anaphase; Signal transduction
语言
英语
类型
Journal Article; Text
2024-02-28
MODS