Alpha-Amylase and Urease Inhibitory Activity of Leaf Extracts of Prunus persica (L.) Batsch
2019
Prakash, Ved | Sagar, Anand
The use of herbal remedies for curing diseases is on the rise in developed as well as developing countries. The current study was undertaken to investigate the leaf extracts of Prunus persica (L.) Batsch for their inhibitory activity against α-amylase and urease enzymes in three different solvents i.e. methanol, acetone and aqueous. The plant showed highest α-amylase enzyme inhibition (75.08±0.28%) at a concentration of 1 mg/mL in methanol extract whereas acetone and aqueous extracts showed moderate inhibition against α-amylase (59.95±1.25 and 50.00±1.00%respectively). In case of urease inhibition, methanol extract exhibited best inhibitory activity (55.08±0.28%) followed by acetone and aqueous extracts at a concentration of 1 mg/mL. The plant extracts showed concentration dependent inhibition of both the enzymes. The inhibitory activity altogether increased with increasing concentration of each plant extract in the range of 0.2–1.0 mg/mL. Moreover, the plant was found more effective against α-amylase than urease. The results further revealed that methanol leaf extracts displayed maximum inhibitory effects than other solvent extracts which tends to show that the active metabolites of the different plant parts are better extracted with methanol than other solvents. Thus the present study provides scientific evidence to the traditional uses of this plant in the treatment of diabetes, obesity, gastric intestinal infections, ulcers, kidney stones etc. Therefore, the leaf extracts of P. persica can be selected for further investigation to discover their ultimate therapeutic potential.
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