Synthesis of parazoanthine B and analogs

Tinto, Francesco; Pagano, Dario; Manzo, Emiliano

Synthesis of parazoanthine B and analogs

2015

Tinto, Francesco | Pagano, Dario | Manzo, Emiliano

A versatile synthesis of the natural product parazoanthine B (2) and its analogs, parazoanthine C (3) and 18-deoxy-parazoanthine B (4), has been accomplished by a key coupling reaction between a hydantoinic compound and an α-bromo-acetophenone derivative. The synthetic approach is designed to address preparation of a wider group of parazoanthine B analogs characterized by the presence of the 5,6-double bond of Z-configuration.

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