Novel genetic variation associated to CSN3 strongly affects rennet-induced milk coagulation
2017
Poulsen, Nina A. | Gregersen, Vivi R. | Maciel, Guilherme M. | Madsen, Lone B. | Buitenhuis, Bart | Hansen, Mikka S. | Bendixen, Christian | Larsen, Lotte B.
The effect on rennet-induced milk coagulation of three novel genetic haplotypes in close proximity to CSN3 encoding κ-casein was evaluated. Milk samples were collected from 71 Danish Holstein cows homozygous for the three novel haplotypes named according to which genetic variants of CSN3 they were characterised by: AE, A and B, respectively. The results documented that haplotype AE had significantly longer rennet coagulation time and lower curd firming rate compared with haplotypes A and B. Haplotype AE milk was further characterised by larger casein micelles and lower relative content of κ-casein, whereas the total protein contents did not differ among haplotypes. These findings indicate that the genetic κ-casein A variant can be divided into two groups with poor and good milk coagulation properties. Furthermore, three milk samples were identified as non-coagulating. These were all associated with the haplotype AE.
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