Pharmacokinetic variables of phenolsulfonphthalein (PSP) were determined in sheep after rapid IV injection and IV infusion to steady state. In Suffolk wethers, an average of < 75% of an IV administered dose was eliminated in urine, indicating that measures of systemic clearance overestimate renal clearance in this species. Furthermore, PSP elimination from plasma was more rapid in Suffolk than Rambouillet wethers and, in Suffolk ewes, systemic clearance decreased from mean +/- SD 7.8 +/- 0.3 ml/min/kg of body weight to 4.7 +/- 1.1 ml/min/kg at steady-state plasma concentration of 2.4 +/- 0.3 and 151.3 +/- 31.8 micrograms/ml, respectively. These observations indicate that, similar to that in other species, systemic clearance of PSP in sheep is concentration-dependent and that significant differences may exist between breeds.
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American journal of veterinary research
卷
54
期
12
页码
2179
- 2183
ISSN
0002-9645
其它主题
Intravenous; Injections; Male; Gender differences; Rambouillet; Female; Administration & dosage; Romanov; Infusions; Intravenous; Phenolsulfonphthalein; Metabolic clearance rate; Suffolk (sheep breed)
语言
英语
注释
2019-12-05
类型
Text; Journal Article
2024-02-28
MODS