Recovery of dietary iron and zinc from the proximal intestine of healthy man: Studies of different meals and supplements
1980
Matseshe, John W. | Phillips, S.F. | Malagelada, Juan-R. | McCall, John T.
Iron and zinc content of the intestinal lumen of 4 healthy subjects was measured by marker perfusion of the gastrointestinal tract following ingestion of hamburger or cereal test meals containing heme (7.5 mg) or inorganic iron (1.4, 5.3 or 4.6 mg), respectively. The meals contained either low (2.4 mg) or high (5.5 mg) levels of zinc. Intubation and perfusion of the proximal intestine permitted comparison of metal absorption (disappearance) from the duodenum and jejunum. Intestinal transit of iron and zinc differed: iron was never recovered from the lumen in higher amounts than intake, unlike zinc. Thus, zinc may be added to the intestinal contents during digestion and absorption. Bioavailability of supplemental iron (ferrous sulfate and reduced iron) added to cereal was similar to that of heme and inorganic iron: absorption of different iron forms was equally rapid. Iron absorption was greatest from the duodenum, while zinc disappearance occurred more distally.
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