A missense mutation in MYO7A is associated with bilateral deafness and vestibular dysfunction in the Doberman pinscher breed
2019
Webb, A. A. | Ruhe, A. L. | Neff, M. W.
Bilateral deafness with concurrent vestibular dysfunction was first reported in the Doberman pinscher in 1980. Here, we identify a coding mutation in the MYO7A gene that is perfectly associated with the disorder. The lack of visual deficits in affected dogs suggests that, like rodents but unlike humans, MYO7A is not required for retinal function. DNA testing of the mutation will enable dog breeders to manage the incidence of this genetic defect.
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书目信息
Canadian journal of veterinary research
卷
83
期
2
页码
142
- 148
ISSN
0830-9000
出版者
Canadian Veterinary Medical Association = Association canadienne des vétérinaires
其它主题
Doberman pinscher; Missense mutation
语言
英语
类型
Text; Journal Article
2024-02-28
MODS