Relationships of pediatric nutrients to lipids, lipoproteins, and ultimate risk of atherosclerosis
1981
Glueck, Charles J. | Morrison, John A.
The potential associations between infant and pediatric nutrient intake and the subsequent risk of atherosclerosis (AS) development are reviewed. These associations appear to be primarily mediated by the relationship of nutrient intake to lipid (L) and lipoprotein (LP) levels, and by subsequent association of L and LP levels to coronary heart disease risk. No longitudinal studies of the relationship of childhood nutrient intake to adult AS risk have been carried out. The relevant data generated in related studies have principally focused on: 1) the statistical association of nutrient intake with L and LP levels in pediatric populations; and 2) the effects of dietary intervention on L and LP in normal and hyperlipidemic children. Results of 2 recent large studies of 1669 (black and white), and 1234 (white) children related to observed correlations of dietary intake (polyunsaturated/saturated fatty acid ratio, total carbohydrate, sugar) with plasma cholesterol and low and high density LP cholesterol are discussed. The effects of dietary modifications on L and LP are summarized. Longitudinal studies covering the period of childhood to adult life are needed to assess the efficacy of childhood dietary modifications in preventing future AS. (wz)
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