Mitochondrial Dysfunction Meets Senescence
2016
Gallage, Suchira | Gil, Jesús
Cellular senescence and mitochondrial dysfunction are hallmarks of ageing, but until now their relationship has not been clear. Recent work by Wiley et al. shows that mitochondrial defects can cause a distinct senescence phenotype termed MiDAS (mitochondrial dysfunction-associated senescence). MiDAS has a specific secretome that is able to drive some of the aging phenotypes. These findings suggest novel therapeutic opportunities for treating age-related pathologies.
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书目信息
出版者
Elsevier Ltd
其它主题
Secretome; Cell senescence; Phenotype; Sasp; Sirtuins
语言
英语
类型
Journal Article; Text
2024-02-28
MODS