Effect of ingestion of meat on plasma cholesterol of vegetarians
1981
Sacks, Frank M. | Donner, Allan | Castelli, William P. | Gronemeyer, James | Pletka, Peter | Margolius, Harry S. | Landsberg, Lewis | Kass, Edward H.
Beef consumption had an adverse effect on plasma lipid level and systolic blood pressure in 21 strict vegetarians during an 8-week study period. Following a 2-week control diet of the usual vegetarian foods, 250 g of beef was added to the daily vegetarian diet for 4 weeks. Subjects were returned to the control diet for an additional 2 weeks. All meals were isocaloric, so that when beef was not included an equivalent number of calories was supplied primarily as grain. Although plasma high density lipoprotein cholesterol was unchanged during the study, plasma total cholesterol increased by 19% after 4 weeks of eating meat. A significant increase of 3% over control values was observed in systolic, but not diastolic blood pressure after the third week of meat eating. Other parameters, including plasma renin activity, weight, prostaglandins A and E, and urinary kallikrein, norepinephrine, sodium and epinephrine excretion remained within normal range throughout the controlled trial, and so were eliminated as confounding variables. (nm)
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