Quality Control in the ER: Misfolded Prohormones Get a Checkup
2019
Sprunger, Macy L. | Jackrel, Meredith E.
In Mutant INS-gene-induced Diabetes of Youth (MIDY) syndrome, mutant proinsulin aggregates interfere with the folding of wild-type proinsulin in the endoplasmic reticulum, ultimately decreasing insulin secretion. In this issue of Molecular Cell, Cunningham et al. (2019) identify two mechanisms by which prohormone aggregation is prevented and cleared.
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书目信息
出版者
Elsevier SAS
其它主题
Insulin secretion; Proinsulin
语言
英语
类型
Journal Article; Text
2024-02-28
MODS