Weight and mortality in the Whitehall study
1982
Jarrett, R.J. | Shipley, M.J. | Rose, Geoffrey
Ten-year mortality rates in 18,393 British male civil servants (ages 40-64) in the 1967-69 Whitehall Study were analyzed relative to weight and height at the initial examination. At ages 40-49, mortality from all causes increased with increasing body mass index (BMI). However, this simple relation disappeared at older ages, showing increased mortality in the lowest BMI quintile. The relation over all ages showed a J-shaped distribution which could not be explained by considering effects of blood pressure, cholesterol levels, and cigarette smoking. Some of the J-shape was due to a high short-term mortality in thin men from cancers, which were presumably already present at examination. Mortality at younger ages from coronary heart attack correlated positively with BMI, but this depended on its association with other risk factors. Excluding cancer and coronary heart disease, mortality from other causes was highest at the lowest BMI quintile. (wz)
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