Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine

Liu, Yingle; Zhang, Ke; Huang, Yangen; Pan, Shen; Liu, Xiao-Qiang; Yang, Yi; Jiang, Yan; Xu, Xiu-Hua

Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine

2016

An unprecedent reaction of indoline-2,3-diones and (triphenylphosphonio)difluoroacetate (PDFA) afforded novel 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles in moderate to excellent yields. These products could be transformed into other trifluoromethylated oxindole derivatives.

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