Conformational Analysis of Benzyloxycarbonyl-Protected Peptides

Knack, Ingo

Conformational Analysis of Benzyloxycarbonyl-Protected Peptides

2014

Knack, Ingo

The benzyloxycarbonyl (Z-) residue, an important protecting group in peptide synthesis, was introduced into the input data set of the “Empirical Conformational Energy Program for Peptides” (ECEPP) developed by Scheraga and coworkers. With additional modifications ECEPP is now prepared for conformational analysis of peptides containing this amino end group. Preferred conformations of the Z-residue were studied by performing calculations on Z-Gly methylamide. The results obtained may be applied to the conformational analysis of Z-protected peptides.

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