Insecticide-insensitive acetylcholinesterase can enhance esterase-based resistance in Myzus persicae and Myzus nicotianae
1994
Moores, G.D. | Devine, G.J. | Devonshire, A.L.
The acetylcholinesterase in some resistant strains of Myzus persicae and its extremely close relative Myzus nicotianae showed marked insensitivity to inhibition by the established carbamate pirimicarb (> 100-fold) and by triazamate, a novel triazole aphicide (> 10-fold), that acts on the same target. There was no insensitivity to a range of other carbamate and organophosphorus insecticides. This resistance mechanism appears to be rare at present and was only found in a heterozygous form associated with the commonly occurring elevated E4/FE4 esterases that confer broad cross-resistance to many aphicides. This insensitive target site mechanism, even when heterozygous, enhances the esterase-based resistance to pirimicarb and triazamate by 15- to 30-fold.
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