Anti‐Inflammatory Effect of Black Raspberry Seed Oil in High‐Fat Diet‐Induced Obese Mice
2015
Yi, Hŭi-jae | Jung, Hana | Cho, Hyunnho | Hwang, Keum Taek
The purpose of the study was to determine the anti‐inflammatory effect of black raspberry seed (BRS) oil on high‐fat diet (HFD)‐induced obese mice. BRS oil was composed of 57.0% linoleic and 29.4% α‐linolenic acids. Five‐week‐old C57BL/6 mice were fed HFD: BRS oil diet consisting of 50% calories from lard and 10% from BRS oil, while control diet consisted of 50% calories from lard, 5% from soybean oil and 5% from corn oil. Inflammation‐involved proteins were lower in the liver of the mice fed the BRS oil than those in the control. mRNA levels of pro‐inflammatory markers in the liver and adipose tissue of the BRS oil group were lower and anti‐inflammatory markers were higher in the BRS oil group compared with the control. The results of this study suggest that BRS oil may be a good source of α‐linolenic acid, an n‐3 fatty acid, with anti‐inflammatory effects on HFD‐induced obese mice. PRACTICAL APPLICATIONS: Black raspberry seed (BRS) oil, which could be obtained from black raspberry wine pomace, contains about 30% α‐linolenic acid, an n‐3 fatty acid. Supplementation of BRS oil might lower inflammation in high‐fat diet‐induced obese mice, when measuring protein and mRNA levels of pro‐ and anti‐inflammatory markers in the liver and adipose tissue of the mice. The results would promote utilization of BRS, a by‐product of wine production, and consequently help black raspberry producers and manufacturers.
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