Prediction of Secondary Structura1 Elements in the Phosphatidylcholine-Transfer Protein from Bovine Liver
1982
AKEROYD, Robert | LENSTRA, Johannes A. | WESTERMAN, Jan | VRIEND, Gerrit | WIRTZ, Karel W.A. | DEENEN, Laurens L.M.
Secondary structural elements of the phosphatidylcholine-transfer protein from bovine liver have been predicted from its primary structure with the aid of two computerized methods. The predicted α-helix and β-strand content have been compared with the values derived from circular dichroism spectra. The hydrophobicity profile (Rose plot) of the protein indicated that the supposed lipid‐binding site occurs in the most hydrophobic region. The predicted secondary structural elements have been folded in a tentative model of the protein molecule according to its hydrophobicity profile.
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