Palladium-catalyzed sequential reaction via Sonogashira coupling, isomerization, Claisen rearrangement and [4 + 2] cycloaddition sequence for the rapid synthesis of tricyclo[3.2.1.0²,⁷]oct-3-ene derivatives

Zhu, Shugao; Wu, Luling; Huang, Xian

Palladium-catalyzed sequential reaction via Sonogashira coupling, isomerization, Claisen rearrangement and [4 + 2] cycloaddition sequence for the rapid synthesis of tricyclo[3.2.1.0²,⁷]oct-3-ene derivatives

2011

Zhu, Shugao | Wu, Luling | Huang, Xian

An interesting sequential reaction consisting of Sonogashira coupling, propargyl–allenyl isomerization, allenyl–benzyl Claisen rearrangement and [4 + 2] cycloaddition was developed. This reaction provides an efficient synthesis of fused tricyclo[3.2.1.0²,⁷]oct-3-enes.

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