Phage display selection of miniprotein binders of the Estrogen Receptor

Phan, Trang; Nguyen, Hoang D.; Göksel, Hülya; Möcklinghoff, Sabine; Brunsveld, Luc

Phage display selection of miniprotein binders of the Estrogen Receptor

2009

Phan, Trang | Nguyen, Hoang D. | Göksel, Hülya | Möcklinghoff, Sabine | Brunsveld, Luc

Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.

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