Phage display selection of miniprotein binders of the Estrogen Receptor
2009
Phan, Trang | Nguyen, Hoang D. | Göksel, Hülya | Möcklinghoff, Sabine | Brunsveld, Luc
Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
The Royal Society of Chemistry
其它主题
Estrogen receptors; Binding capacity; Peptide libraries
语言
英语
类型
Journal Article; Text
2024-02-28
MODS