Maculosin: a host-specific phytotoxin from Alternaria alternata on spotted knapweed
1990
Strobel, G. | Stierle, A. | Park, S.H. | Cardellina, J.
A strain of Alternaria alternata on spotted knapweed produces a family of diketopiperazines including maculosin, which is an L-tyrosine-L-proline analog. Maculosin is a host-specific toxin of Centaurea maculosa L. (spotted knapweed), the only one currently known from a weed pathogen. Current studies are underway to isolate and characterize a cytosol (soluble) protein receptor for maculosin in spotted knapweed. Affinity column chromatography employing maculosin covalently bonded to Sepharose 6-B has been used successfully to isolate an active protein fraction. Another phytotoxin produced by A. alternata, tenuazonic acid, acts in a synergistic manner with maculosin. Phytotoxin production in A. alternata seems to depend on one or more host plant metabolites.
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