Palladium catalyzed addition of arylboronic acid or indole to nitriles: synthesis of aryl ketones

Das, Tuluma; Chakraborty, Amarnath; Sarkar, Amitabha

Palladium catalyzed addition of arylboronic acid or indole to nitriles: synthesis of aryl ketones

2014

Das, Tuluma | Chakraborty, Amarnath | Sarkar, Amitabha

Aryl ketones can be synthesized conveniently by a palladium catalyzed addition of arylboronic acid to nitriles in aqueous triflic acid. This catalytic system was extended to the addition of unprotected indoles to nitriles under a slightly modified condition to produce 3-acyl indoles in good yields.

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