Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids
2003
Čipák, Luboš | Novotný, Ladislav | Čipáková, Ingrid | Rauko, Peter
We studied the ability of five structurally related flavonoids (quercetin (QU), luteolin (LU), apigenin (AP), galangin (GA) and chrysin (ChR)) to modulate chemotherapeutic efficacy and affect chemotherapy-induced apoptosis and cell cycle arrest of murine leukemia L1210 cells. We found that QU and LU potentiated cytotoxicity of cisplatin, however the other flavonoids (AP, GA and ChR) decreased its cytotoxic effect. We proved that QU and LU positively modulated efficacy of cisplatin due to increasing of cisplatin-induced apoptotic cell death. In combination with doxorubicin all tested flavonoids decreased doxorubicin cytotoxicity and caused cells to shift from G2/M to S phase of the cell cycle. The findings that flavonoids can differentially modulate the efficacy of chemotherapeutics through interfering with chemotherapy-induced apoptosis or cell cycle arrest further improve our understanding of possible impacts of some dietary agents on chemotherapeutic intervention.
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