Dosage compensation in drosophila: Sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome
2010
Gorchakov, Andrey A | Alekseyenko, Artyom A | Kharchenko, Peter V | Park, Peter J | Kuroda, Mitzi I
For the dosage compensation to occur, genes on the single male X chromosomes in Drosophila must be selectively bound and acetylated by the ribonucleoprotein complex called MSL complex. It remained unknown how such exquisite specificity is achieved, and whether specific DNA sequences were involved. In the present work we demonstrate that it is transcription of the gene on the X chromosome that is important for MSL targeting, irrespective of gene origin and DNA sequence.
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书目信息
出版者
Dordrecht : SP MAIK Nauka/Interperiodica
其它主题
Nucleotide sequences; X chromosome; Transcription (genetics)
语言
英语
类型
Journal Article; Text
2024-02-28
MODS