Aryl methyl sulfides via SNAr using DMSO as the source of the thiomethyl moiety
2014
Jones-Mensah, Ebenezer | Magolan, Jakob
A unique synthesis of aryl methyl sulfides is reported proceeding via reduction of dimethylsulfoxide to dimethylsulfide at elevated temperature in the presence of Hunig’s base followed by nucleophilic aromatic substitution and demethylation. Activated aryl fluorides, chlorides, and nitrobenzenes are suitable substrates with 13 examples provided. Dimethylsulfoxide serves as a simple and inexpensive formal source of the thiomethyl moiety.
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书目信息
出版者
Elsevier Ltd
其它主题
Dimethylsulfoxide; Hunig’s base; Methyl sulfides; Nucleophilic aromatic substitution; Dimethyl sulfide; Lewis bases; Nitrobenzenes; Moieties; Thiomethyl; Dimethyl sulfoxide
语言
英语
类型
Journal Article; Text
2024-02-28
MODS