A stable-isotope study of zinc, copper, and iron absorption and retention by young women fed vitamin B-6-deficient diets
1991
Turnlund, J.R. | Keyes, W.R. | Hudson, C.A. | Betschart, A.A. | Kretsch, M.J. | Sauberlich, H.E.
A 98-d study was conducted in young women to determine the effect of vitamin B-6-deficient diets on zinc, copper, and iron metabolism. Young women were fed vitamin B-6-deficient formula initially, followed by food diets containing four increasing amounts of vitamin B-6. Zinc, copper, and iron absorption, retention, and status were determined at intervals throughout the study. Zinc absorption and retention were greater during vitamin B-6 depletion but serum zinc declined, suggesting that absorbed zinc was not available for utilization. Copper absorption was lower during vitamin B-6 depletion but serum copper was not affected and balance was positive. Iron absorption was not impaired significantly by vitamin B-6-deficient diets but status may have declined. The results suggest that vitamin B-6 depletion of young women may alter zinc metabolism, inhibit copper absorption, and affect iron status. The effects of vitamin B-6 depletion differ markedly among these elements.
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