Jatrophane polyesters from the leaves of Euphorbia peplus with anti-inflammatory activity
2022
Li, Ying-Yao | Yang, Ying | Sun, Mao | Lu, Qing-Yun | Pu, Xue-Xue | Ran, Xiaoqian | Li, Dong-Mei | Wan, Jia-Jia | Huang, Jian-Yi | Guan, Shi-Peng | Luo, Rongcan | Cheng, Yuan-Yuan | Di, Ying-Tong | Hao, Xiao-Jiang
Three new jatrophane polyesters, Euphopepluanones M-O (1–3), along with eight known ones (4-11), were isolated from the leaves of Euphorbia peplus Linn. Their chemical structures were established based on extensive spectroscopic analysis. The absolute configurations of compound 1 were assigned by X-ray crystallographic analysis. In addition, their anti-inflammatory effects on lipopolysaccharide-induced RAW264.7 macrophages were evaluated in vitro. Among them, 2 and 7 exhibited significant anti-inflammatory activity.
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