Biodegradable polymer network encapsulated polyplex for DNA delivery

Petrov, Petar D.; Ivanova, Nadya I.; Apostolova, Margarita D.; Tsvetanov, Christo B.

Biodegradable polymer network encapsulated polyplex for DNA delivery

2013

Petrov, Petar D. | Ivanova, Nadya I. | Apostolova, Margarita D. | Tsvetanov, Christo B.

A novel gene delivery system is made by encapsulation of a polyplex between pDNA and cationic micelles with a biodegradable crosslinked shell. The outer shell can provide additional functionality to the system and protect DNA from degradation. The encapsulated polyplex exhibits a similar transfection efficiency compared to the naked polyplex.

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