PPh₃-mediated intramolecular conjugation of alkyl halides with electron-deficient olefins: facile synthesis of chromans and relevant analogues

Zhu, Jian-Bo; Wang, Peng; Liao, Saihu; Tang, Yong

PPh₃-mediated intramolecular conjugation of alkyl halides with electron-deficient olefins: facile synthesis of chromans and relevant analogues

2013

Zhu, Jian-Bo | Wang, Peng | Liao, Saihu | Tang, Yong

With the mediation of phosphine, the direct intramolecular coupling of two electrophiles – alkyl halides with electron-deficient olefins – has been successfully realized in an intramolecular conjugate addition manner. The reaction provides a new approach for the synthesis of chromans and relevant analogues.

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