Verbenone Structural Analogues Isolated from Artemesia aucheri as Natural Acaricides against Dermatophagoides spp. and Tyrophagus putrescentiae
2013
Yang, Ji-Yeon | Lee, Hoi-Seon
The acaricidal activities of Artemisia aucheri oil and (1S)-(−)-verbenone structural analogues were evaluated using a fumigant method against Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae and then compared to those of benzyl benzoate. On the basis of the LD₅₀ values against D. farinae, (1S)-(−)-verbenone (1.38 μg/cm²) was about 7.4 times more active than benzyl benzoate (10.15 μg/cm²), followed by (+)-trans-myrtanol (2.27 μg/cm²), (−)-trans-myrtanol (2.30 μg/cm²), and A. aucheri oil (8.75 μg/cm²). (1S)-(−)-Verbenone (1.25 μg/cm²) was approximately 7.8 times more effective against D. pteronyssinus than benzyl benzoate (9.80 μg/cm²), followed by (+)-trans-myrtanol (2.18 μg/cm²), (−)-trans-myrtanol (2.22 μg/cm²), and A. aucheri oil (8.46 μg/cm²). In the case of T. putrescentiae, (1S)-(−)-verbenone (3.75 μg/cm²) was roughly 3.5 times more toxic than benzyl benzoate (13.25 μg/cm²), followed by (+)-trans-myrtanol (12.57 μg/cm²), (−)-trans-myrtanol (12.95 μg/cm²), and A. aucheri oil (11.55 μg/cm²). These results indicate that A. aucheri oil and (1S)-(−)-verbenone structural analogues may be effective natural agents to control house dust and storage mites.
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