The adipocyte volume in human adipose tissue: 1. Lipid space, normal and maximum values, and the relation to body weight index
1978
Leonhardt, Wolfgang | Hanefeld, Markolf | Haller, Hans
Extract: The volume of isolated adipocytes in specimens from the subcutis of the abdomen was measured using the pulse counter technique. The lipid content was determined as esterified fatty acids. Results include the following: (1) Adipocyte enlargement is mainly caused by lipid deposition, despite a slight increase in the lipid free volume; (2) An analysis of large numbers of cells in single specimens revealed the lognormal type to fit the volume distribution better than the normal type; (3) Standard deviations of the lognormal distrbutions decrease with the mean cell volumes. Calculation by extrapolation shows the maximum adipocyte volume is of the order of 1 nl; and (4) The normal adipocyte volume in ideal weight persons without metabolic disease is in the order of 0.3 nl.
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