5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide; direct preparation, and its application for the synthesis of 5-substituted furan derivatives

Rieke, Reuben D.; Kim, Seung-Hoi

5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide; direct preparation, and its application for the synthesis of 5-substituted furan derivatives

2011

Rieke, Reuben D. | Kim, Seung-Hoi

5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide was easily prepared by the direct insertion of active zinc to 2-bromo-5-(1,3-dioxolane)furan under mild conditions. Of interest, the resulting organozinc was successfully coupled with aryl halides and acid chlorides affording the corresponding coupling products in good to excellent yields.

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