Separation of antioxidant and α-glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus
2017
Wang, Yan Ming | Zhao, Jian-Qiang | Yang, Jun-Li | Tao, Yan-Duo | Mei, Li-Juan | Shi, Yan-Ping
A new flavonoid, along with 16 known ones, was separated from the aerial parts of Asterothamnus centrali - asiaticus . Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR techniques and HRESIMS. To confirm the structure of the new compound, computational prediction of its ¹³C chemical shifts was performed. All of the 17 flavonoids were reported from A. centrali - asiaticus for the first time. In addition, all flavonoids were evaluated for their antioxidant and α -glucosidase inhibitory activities. The results showed that 10 of them exhibited antioxidant activity. Meanwhile, four flavonoids displayed α -glucosidase inhibitory effect with IC ₅₀ values ranging from 38.9 to 299.7 μM.
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