Antifungal activity of a novel chromene dimer
2007
Abrunhosa, L. | Costa, M. | Areias, F. | Venâncio, A. | Proença, F.
The activity on Aspergillus spp. growth and on ochratoxin A production of two novel chromene dimers (3) was evaluated. The results of the bioassays indicate that the chromene dimer 3a inhibited mycelia growth by approximately 50% (EC₅₀) at 140.1 μmol L-¹ for A. niger, 384.2 μmol L-¹ for A. carbonarius, 69.1 μmol L-¹ for A. alliaceus and 559.1 μmol L-¹ for A. ochraceus. When applied at concentrations of 2 mmol L-¹, 3a totally inhibited the growth of all Aspergillus spp. tested. Furthermore, ochratoxin A production by A. alliaceus was reduced by about 94% with a 200 μmol L-¹ solution of this compound. A moderate inhibitory effect was observed for the analogous structure 3b on ochratoxin A production but not in mycelia growth. No inhibition was registered for compounds 2a and 2b, used as synthetic precursors of the dimeric species 3.
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