An efficient preparation of 2-alkyl-oxazoles from 2-iodooxazoles
2013
Zhang, Xing | Liu, Jun | Liu, Yi | Du, Yuguo
An efficient synthesis toward 2-alkyl substituted oxazoles has been achieved through Suzuki cross-coupling reaction. Treatment of various alkyl iodides with 9-MeO-BBN, followed by in situ palladium-catalyzed carbon–carbon formation with 2-iodooxazoles obtained the 2-alkyl substituted oxazoles in good to excellent yields. Regioselective C2-alkylation on 2,4-di-iodooxazole under the same reaction conditions was firstly disclosed.
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书目信息
出版者
Elsevier Ltd
其它主题
Oxazoles; 2-alkyl oxazoles; Suzuki reaction; Regioselective alkylation; Iodooxazole
语言
英语
类型
Journal Article; Text
2024-02-28
MODS