Preparation of 1,2-Oxazetidines from Styrenes and Arylamines via a Peroxide-Mediated [2 + 1 + 1] Cycloaddition Reaction
2017
Liu, Weibing | Chen, Cui | Zhou, Peng | Tan, Hua
The first regioselective synthesis of polysubstituted 1,2-oxazetidines, based on the [2 + 1 + 1] radical tandem cycloaddition of styrenes, arylamines, and tert-butyl hydroperoxide (TBHP), is described. This simple and direct method allows the synthesis of 1,2-oxazetidines with a broad substrate scope from easily accessible materials. TBHP was employed in this conversion not only as the oxidant but also as the source of “O” for the carbonyl group in the products.
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书目信息
出版者
American Chemical Society
其它主题
Moieties; Regioselectivity; Cycloaddition reactions
语言
英语
类型
Journal Article; Text
2024-02-29
MODS