Synthesis of novel d-α-galactopyranosyl-l-seryl/l-threonyl-l-alanyl-l-alanine as useful precursors of new glycopeptide antibiotics with computational calculations studies
2022
Khodair, Ahmed I. | Kassab, Shaymaa E. | Kheder, Nabila A. | Fahim, Asmaa M.
New, simple, synthetic routes for the preparation of novel glycopeptide antibiotics are described. The structures of the synthesized compounds are elucidated by IR, two-dimensional NMR spectroscopy, and mass spectrometry. The stability of the new glycopeptide derivatives 10a,b is confirmed by assessing the physical character, HOMO-LUMO gap energy, ESP, and the corresponding correlation of 2D-NMR analysis. Furtherly, the target precursors are investigated via the DFT/B3LYP/6–311(G) basis set.
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书目信息
出版者
Elsevier Ltd
其它主题
N-boc-protected amino acids esters; Peptide mimetic; Theoretical investigation; Glycopeptide derivatives
语言
英语
类型
Journal Article; Text
2024-02-29
MODS