Acylphloroglucinol profile and antichemotactic activity of lipophilic extracts from Peruvian Hypericum species
2018
Ccana-Ccapatinta, Gari V. | Kaiser, Samuel | Danielli, Leticia J. | Dresch, Roger R. | D’Avila, Felipe B. | Fröehlich, Pedro E. | Ortega, George G. | Apel, Miriam A. | von Poser, Gilsane L.
Lipophilic extracts of Hypericum species are described to possess diverse potential bioactivities, however there is no report on the potential anti-inflammatory activity of Peruvian Hypericum species. Investigating the chemotactic ability plays an important role in the study of new anti-inflammatory agents. Thus, the present research aimed to assay the antichemotactic activity of lipophilic extracts of six Peruvian Hypericum species, as well as to characterize their acylphloroglucinol composition. Qualitative analyses by reverse phase liquid chromatography associated with diode array detection and mass spectrometry lead to the identification and putative assignation of 22 dimeric acylphloroglucinols in the Hypericum lipophilic extracts. The antichemotactic activity of the lipophilic extracts and uliginosin B, a common constituent among the extracts, were assayed in the lipopolysaccharide-induced chemotaxis on rat polymorphonuclear neutrophils. The lipophilic extracts of Peruvian Hypericum species displayed antichemotactic activity in the dose range of 10–0.3 μg/mL, while uliginosin B showed an IC50 value of 0.26 μM. The present research demonstrates that the lipophilic extracts of Peruvian Hypericum species contain a rich diversity of dimeric acylphloroglucinols and display significant antichemotactic activity.
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