An efficient scale up process for synthesis of N-arylpiperazines
2015
Ravilla, Lokesh | Venkata Subba Naidu, N. | Nagarajan, Kuppuswamy
An efficient protocol for the synthesis of various substituted phenylpiperazines was developed using sulfolane as solvent. The protocol was clean, high yielding and products were obtained in high purities (⩾99%). It was also fast and convenient, as the final products were precipitated as hydrochloride salts and could be obtained by filtration. Sulfolane, an aprotic, dipolar, high boiling and recoverable solvent was used as a substitute for common organic solvents.
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书目信息
出版者
Elsevier Ltd
其它主题
Scale up; Sulfolane; N-arylpiperazines; High purity
语言
英语
类型
Journal Article; Text
2024-02-29
MODS