Adipose reduction by beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16)
1989
Tzur, R. | Smith, E. | Bar-Tana, J.
Treatment of normal rats kept on a balanced laboratory chow diet with beta, beta-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) (Bar-Tana el al.. 1985, J. Biol. Chem. 260, in adiposity, which was already established during, the 8404-8410) resulted in an acute reduction first week of treatment and was sustained as long as the drug was administered. Adipose reduction consisted of 30-80 percent decrease in the perirenal, omental, epididymal, parametrial and subcutaneous fat with a concomitant 50 percent decrease in total body, natural lipid mass. The reduction in adiposity was accounted for by a respective decrease in the lipid content of individual adipocytes together with a transient or sustained decrease in the number of adipocytes of selected adipose tissues. The decrease in the lipid content resulted from (a) an extensive hypotriglyceridemia demia in MEDICA 16-treated rats; (b) inhibition of adipose lipogenesis by MEDICA 16; (c) increased sensitivity to catecholamines-, ACTH- acid forskolin-induced lipolysis in MEDICA 16 adipocytes. Adipose reduction by MEDICA 16 was not compromised by a decrease in overall net caloric intake but was accompanied by a 40 percent increase in resting metabolic rate.
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