Three-Component Radical Iodonitrosylative Cyclization of 1,6-Enynes under Metal-Free Conditions
2021
Zhu, Shaoqun | Cheng, Qi | Yang, Haibo | Chen, Xiaoyun | Han, Ying | Yan, Chaoguo | Shi, Yaocheng | Hou, Hong
A three-component, metal-free radical cascade iodonitrosylative cyclization reaction was described. The nitroso radical was generated from tert-butyl nitrite and triggered the radical addition/cyclization/iodination/oxidation sequences. A variety of 1,6-enynes were tested and proved to be compatible, delivering various highly functionalized hetero- and all-carbon cycles and nitro and vinyl C–I bonds containing pyrrolidines, tetrahydrofuran, and cyclopentane in moderate to excellent isolated yields.
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