Evidences for leishmanicidal activity of the naphthoquinone derivative epoxy-α-lapachone
2014
Souza-Silva, Franklin | do Nascimento, Samara Braga | Bourguignon, Saulo Cabral | Pereira, Bernardo Acácio Santini | Carneiro, Paula Fernandes | da Silva, Wellington Seguis | Alves, Carlos Roberto | de Pinho, Rosa Teixeira
In this work, we analyze the leishmanicidal effects of epoxy-α-lapachone on Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis. Promasigotes and amastigotes (inhabiting human macrophages) from both species were assayed to verify the compound's activity over the distinct morphological stages. The incubation with epoxy-α-lapachone led to a significant decrease in the numbers of promastigotes from both species in the cultures, in a dose-and time-dependent fashion. The survival of amastigotes inhabiting human macrophages was also drastically affected by the compound, as shown by the variations in the endocytic index. Our results indicate that the epoxy-α-lapachone has an antiparasitic effect over Leishmania in both morphological stages and may potentially affect a range of species in two distinct subgenera of this parasite.
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