Photoredox-catalysed formal [3+2] cycloaddition of N-aryl α-amino acids with isoquinoline N-oxides
2019
Liu, Xiangyuan | Yin, Yanli | Jiang, Zhiyong
A formal [3+2] cycloaddition of N-aryl α-amino acids with isoquinoline N-oxides via visible light-driven photoredox catalysis is reported. Under transition metal-free conditions using a dicyanopyrazine-derived chromophore (DPZ) as the photoredox catalyst, the transformation was efficient and led to a series of important diazabicyclo[3.2.1]octane-based N-heterocyclic compounds. This work demonstrates the synthetic utility of N-aryl α-amino acids as 1,2-synthons and provides a new strategy for the dearomatization of isoquinolines.
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书目信息
出版者
The Royal Society of Chemistry
其它主题
Isoquinolines; Cycloaddition reactions
语言
英语
类型
Journal Article; Text
2024-02-29
MODS