Bond reactivity indices approach analysis of the [2+2] cycloaddition of jatrophane skeleton diterpenoids from Euphorbia gaditana Coss to tetracyclic gaditanone
2020
Flores-Giubi, M Eugenia | Botubol-Ares, Jose Manuel | Durán-Peña, María J. | Escobar-Montaño, Felipe | Zorrilla, David | Sánchez-Márquez, Jesús | Muñoz, Eduardo | Macías-Sánchez, Antonio J. | Hernández-Galán, Rosario
The reaction mechanism of the intramolecular [2 + 2] cycloaddition from a jatrophane precursor to the gaditanane skeleton, an unprecedented 5/6/4/6-fused tetracyclic ring framework recently isolated from Euphorbia spp., was studied using the bond reactivity indices approach. Furthermore, six diterpenoids, including three undescribed jatrophanes isolated from E. gaditana Coss, were described. The structures of these compounds were deduced by a combination of 2D NMR spectroscopy and ECD data analysis.
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