Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate
2015
Salamone, Stéphane | Guerreiro, Catherine | Cambon, Emmanuelle | André, I. (Isabelle) | Remaud-Siméon, Magali | Mulard, Laurence A.
The powerful chemo-enzymatic synthesis of the pentadecasaccharide hapten involved in the first synthetic carbohydrate-based vaccine candidate against endemic shigellosis is reported. The high yielding site-selective α-d-glucosylation of a lightly protected disaccharide by an engineered transglucosylase–sucrose system gave a trisaccharide, which was chemically elongated by an efficient [5+5] process.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
The Royal Society of Chemistry
其它主题
Trisaccharides; Shigellosis
语言
英语
类型
Journal Article; Text
2024-02-29
2026-02-03
MODS