Relationship between serum somatomedin C levels and tissue selenium content among adults living in a seleniferous area
1993
Salbe, A.D. | Hill, C.H. | Veillon, C. | Howe, M. | Longnecker, M.P. | Taylor, P.R. | Levander, O.A.
Depressed serum somatomedin C levels have been suggested by others as an early indicator of selenium (Se) toxicity. In both human and animal studies, somatomedin C levels were lower in Se supplemented as compared to control subjects. The present study examined Se and somatomedin C levels in 44 adult long-term residents of seleniferous areas in South Dakota. Serum Se (SSe) and whole blood Se (WBSe) levels were analyzed by GC/MS. Toenail Se (TSe) was measured by neutron activation analysis. Somatomedin C was analyzed by RIA assay. Subjects were divided into 3 groups based on the following criteria: group I, SSe <200, WBSe <320 ng/ml; group II, SSe 201-240, WBSe 321-400 ng/ml; group III, SSe >240, WBSe >400 ng/ml. Data were pooled across gender (20 males, 24 females). Somatomedin C levels were not different despite greater than 50% differences in SSe, WBSe, and TSe levels among the groups. In these subjects, somatomedin C was not a sensitive index of elevated Se exposure.
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