Delayed progression of rabies transmitted by a vampire bat
2016
Katz, Iana Suly Santos | Fuoco, Natalia Langenfeld | Chaves, Luciana Botelho | Rodrigues, Adriana Candido | Ribeiro, Orlando Garcia | Scheffer, Karin Corrêa | Asano, Karen Miyuki
Here, we compared the growth kinetics, cell-to-cell spread, and virus internalization kinetics in N2a cells of RABV variants isolated from vampire bats (V-3), domestic dogs (V-2) and marmosets (V-M) as well as the clinical symptoms and mortality caused by these variants. The replication rate of V-3 was significantly higher than those of V-2 and V-M. However, the uptake and spread of these RABV variants into N2a cells were inversely proportional. Nevertheless, V-3 had longer incubation and evolution periods. Our results provide evidence that the clinical manifestations of infection with bat RABV variant occur at a later time when compared to what was observed with canine and marmoset rabies virus variants.
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