Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage

Shin, Hijai R.; Zoncu, Roberto

Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage

2018

Shin, Hijai R. | Zoncu, Roberto

In this issue of Molecular Cell, Jia et al. (2018) identify a lysosomal damage-response pathway centered on galectin 8 and 9 that feeds back on mTORC1 signaling. In response to lysosome-damaging agents, galectins inhibit mTORC1, triggering a stress response that may help restore cellular homeostasis.

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